Symbol
Name
ID

Pkd2
polycystin 2, transient receptor potential cation channel
MGI:1099818

Phenotype annotations related to liver/biliary system

Darker colors indicate more annotations

Human Phenotypes	Hepatomegaly	Hepatic cysts	Polycystic liver disease	Jaundice
Disease(s) Associated with PKD2	Hepatomegaly	Hepatic cysts	Polycystic liver disease	Jaundice
autosomal dominant polycystic kidney disease
polycystic kidney disease 2

Mouse Phenotypes

abnormal cholangiocyte primary cilium morphology

increased cholangiocyte apoptosis

abnormal cholangiocyte morphology

bile duct proliferation

dilated bile duct

liver cyst

enlarged liver

increased liver weight

abnormal liver development

abnormal liver morphology

liver fibrosis

Availability

Mouse Genotype

Pkd2^tm1Dwo/Pkd2^tm1Dwo

Pkd2^tm1Gwu/Pkd2^tm1Gwu

Pkd2^tm1Som/Pkd2^tm1Som

Pkd2^tm1Som/Pkd2^tm2Som

Pkd2^tm2Som/Pkd2⁺

Pkd2^tm1.1Gwu/Pkd2^tm1.1Gwu
Tg(Vil1-cre)997Gum/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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